Ethnopharmacological relevance: seeds of Anethum graveolens have been used in the Indian traditional medicine to relieve stress and other neurological disease conditions. Aim of the study: The present study was under taken to evaluate the antidepressant effects of seeds of Anethum graveolens Ethanolic Extract (AGEE) in mice. Materials and methods: seeds of Anethum graveolens Ethanolic extract was screened for antidepressant effect by using forced swim test at doses of 100 and 200 mg/kg. Distilled water and Imipramine were employed as negative and positive control groups, respectively. Results: antidepressant effect assessment of seeds of Anethum graveolens Ethanolic Extract (AGEE) 200 mg/kg shows significantly decrease in immobility time (24.44 %) as compared to standard (46.67 %) treatment group. Conclusion: The results of this study established a support for the traditional usage of seeds of Anethum graveolens as antidepressant medicinal plant.